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Prolia is the brand name for denosumab, and it works differently from Zometa. So how does Prolia work? Prolia targets a protein called RANKL. RANKL helps activate osteoclasts the cells responsible for breaking down bone. Prolia blocks RANKL. That decreases osteoclast formation and activity, which means less bone resorption and stronger bones. This can be particularly important for women experiencing bone loss from aromatase inhibitor therapy. How is Prolia given? Prolia is not an IV infusion. It
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