An investigational vaccine helped the immune system recognize and respond to mutations that drive most pancreatic cancers, ...

An expert at ESMO 2026 explains how liquid biopsy and ESR1 testing can help guide treatment for people with HR-positive metastatic breast cancer. A simple blood test can help oncologists track how ...

A targeted drug from Incyte, when used in combination with chemotherapy, induced lasting tumor responses in certain patients ...

Moderate levels of mitochondrial DNA mutations may promote cancer more effectively than either low or high levels. And metabolic plasticity appears to be a key driver. After decades of fixating on ...

Depending on dose, firmonertinib shrank tumors in 43% to 68% of patients as a first treatment for EGFR PACC-mutant lung ...

Cancer is often thought of as a single disease. Yet even tumors that arise in the same organ can follow very different genetic paths. A new study shows that these differences can sometimes be traced ...

Cancers can develop through epigenetic pathways even without driver gene mutations (DGMs), according to a study from Science ...

KRAS mutations lead to excessive cell growth due to alterations in the KRAS gene. They are present in a significant percentage of non-small cell lung cancers (NSCLC). Diagnosis involves testing ...

An observational study of 3.3 million research participants found that inherited EGFR T790M was associated with 25-fold higher lung cancer risk overall and more than 60-fold risk among never-smokers.

What happens to the thousands of intestinal cells that have tumour-initiating DNA mutations? A study in mouse models shows that most are eliminated by strong negative selection, but those that survive ...

A single sperm donor who carries a rare cancer-causing genetic mutation has fathered at least 197 children across 14 countries in Europe, according to a collaborative investigation by 14 European news ...

Specialists explain how family history, inherited mutations and lifestyle factors influence risk ...